Immunotoxicology; role of macrophages and inflammatory mediators in tissue injury; immune mechanisms mediating the pulmonary toxicity of air pollutants (e.g., ozone, particulates) and hepatotoxicity of acetaminophen; biochemical mechanisms mediating macrophage activation ;investigations on signaling molecules including MAP kinases and transcription factors such as NFkB, C/EBP and AP-1.

Sunil, V.R., Patel, K.J., Nielson-Hamilton, M., Laskin, J.D., and Laskin, D.L. Induction of lipocalin 24p3 in lung and liver during acute endotoxemia. Experimental and Molecular Pathology, in press.

Gray JP, Heck DE, Mishin V, Smith PJ, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, and Laskin JD. (2007). Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H: Paraquat Oxidoreductase: Identification of the enzyme as thioredoxin reductase. Journal of Biological Chemistry, in press.

Weinberger, B., Vetrano, A., Murthy, S., Syed, K., Hanna, N., Laskin, J.D., and Laskin, D.L. (2007). Influence of labor on neonatal neutrophil apoptosis and inflammatory activity. Pediatric Research, in press.

Dambach, D., Durham, S., Laskin, J.D., and Laskin, DL. (2006). Distinct roles of NF-??B p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity. Toxicology and Applied Pharmacology, 211: 157-165.

Vetrano, A.M., Heck, D.E., Mariano, T.M., Mishin, V.M., Laskin, D.L., and Laskin, J.D. (2005). Characterization of the oxidase activity in mammalian catalase, Journal of Biological Chemistry, 280: 35372-35381.

Weinberger, B., Hanna, N., Laskin, J.D., Heck, D.E., Gardner, C.R., Gerecke, D.R., and Laskin, D.L. (2005). Mechanisms mediating the biologic activity of synthetic proline, glycine and hydroxyproline polypeptides in human neutrophils. Mediators of Inflammation, 1: 31-38.

Hanna, N., Vasquez, P., Pham, P., Heck, D.E., Laskin, J.D., Laskin, D.L. and Weinberger, B. (2005). Mechanisms underlying reduced apoptosis in neonatal neutrophils. Pediatric Research, 57: 56-62.

Fakhrzadeh, L., Laskin, J.D., Laskin, D.L. (2004). Ozone-induced production of nitric oxide and TNF?? and tissue injury are dependent on NF-kB. American Journal of Physiology. Lung Cell Physiology, 287(2):L279-285.

Fakhrzadeh, L., Laskin, J.D., Gardner, C.R., Laskin, D.L. (2004). Resistance of SOD / mice to ozone toxicity and increases in nitric oxide and TNF-a production. American Journal of Respiratory Cell and Molecular Biology, 30:280-287.

Sunil, V.R., Patel, K.J., Laumbach, R., Turpin, B.J., Lim, H.-J., Laskin, Laskin, D.L. (2007). Pulmonary effects of inhaled limonene oxidation products in elderly rats. Toxicology and Applied Pharmacology, 222: 211-220.

1999 Dolph Adams Award from the Society for Leukocyte Biology (for the most cited research publication in the Journal of Leukocyte Biology during the past five years entitled "Production of the Nitric Oxide and Peroxynitrite in the Lung During Endotoxema"),

1993 Burroughs Wellcome Toxicology Scholar Award

1991 Society of Toxicology Achievement Award

1989 Society for Leukocyte Biology Young Investigator Research Award

1988 Board of Publications Award (formerly Frank R. Blood Award), Society of Applied Pharmacology entitled: "Potential Role of Macrophages in Hepatotoxicity")